Evaluation of Phytochemicals and Anticancer Potential of <i>C. maxima</i>: An <i>In-silico</i> Molecular Docking Approach

Cucurbita maxima belongs to the Cucurbitaceae family and has many traditional medicinal properties claimed that are used in food. The various parts of reported have versatile activities such as antimicrobial, antioxidant, anti-insecticidal, anti-inflammatory anticancer properties. current study was designed evaluate phytoconstituent profiles C. pulp, peel seed extracts (aqueous methanol) extracted at different temperatures (40 °C, 50 60 °C) time (1 2 hr). For these extracts, qualitative quantitative determination were performed, aqueous extract °C for hours had higher phytoconstituents, which further taken GCMS analysis. Furthermore, top hit compounds from Guanosine (CAS), 8,11,14-Eicosatrienoic acid, Farnesol 13-Tetradecenal docked against p53 Y220S mutant (6SI2), Fibroblast growth factor receptor 1 protein (FGFR1) (4V05). results revealed with acid FGFR1 good binding affinities -7.2 -6.3 kcal/mol respectively. Conclusively, significant breast cancer activity it be vitro vivo studies future.